Scientific papers related to BALTYMAS products and their applications:

Plikusiene I, Maciulis V, Vertelis V, Juciute S, Balevicius S, Ramanavicius A, Talbot J, Ramanaviciene A: Revealing the SARS-CoV-2 Spike Protein and Specific Antibody Immune Complex Formation Mechanism for Precise Evaluation of Antibody Affinity. Int J Mol Sci. 2023 Aug 25;24(17):13220. doi: 10.3390/ijms241713220.


Reinikovaite V, Matulevicius M, Elsakova A, Drobysh M, Liustrovaite V, Luksa A, Jafarov A, Slibinskas R, Ramanavicius A, Baradoke A: Electrochemical capacitance spectroscopy based determination of antibodies against SARS-CoV-2 virus spike protein. Sci Total Environ. 2023 Aug 19;903:166447. doi: 10.1016/j.scitotenv.2023.166447.


Meškinis Š, Gudaitis R, Vasiliauskas A, Guobienė A, Jankauskas Š, Stankevič V, Keršulis S, Stirkė A, Andriukonis E, Melo W, Vertelis V, Žurauskienė N: Biosensor Based on Graphene Directly Grown by MW-PECVD for Detection of COVID-19 Spike (S) Protein and Its Entry Receptor ACE2. Nanomaterials (Basel). 2023 Aug 18;13(16):2373. doi: 10.3390/nano13162373.


Warrener L, Andrews N, Koroma H, Alessandrini I, Haque M, Garcia CC, Matos AR, Caetano B, Lemos XR, Siqueira MM, Samuel D, Brown DW: Evaluation of a rapid diagnostic test for measles IgM detection; accuracy and the reliability of visual reading using sera from the measles surveillance programme in Brazil, 2015. Epidemiol Infect. 2023 Aug 4:1-34. doi: 10.1017/S0950268823000845.


Plikusiene I, Maciulis V, Juciute S, Ramanavicius A, Ramanaviciene A: Study of SARS-CoV-2 Spike Protein Wild-Type and the Variants of Concern Real-Time Interactions with Monoclonal Antibodies and Convalescent Human Serum. Biosensors (Basel). 2023 Aug 3;13(8):784. doi: 10.3390/bios13080784.


Kyllesbech C, Trier N, Mughal F, Hansen P, Holmström M, El Fassi D, Hasselbalch H, Skov V, Kjær L, Andersen M, Ciplys E, Slibinskas R, Frederiksen J, Højrup P, Houen G: Antibodies to calnexin and mutated calreticulin are common in human sera. Curr Res Transl Med. 2023 Apr-Jun;71(2):103380. doi: 10.1016/j.retram.2023.103380.


Drobysh M, Ramanavicius A, Baradoke A: Polyaniline-based electrochemical immunosensor for the determination of antibodies against SARS-CoV-2 spike protein. Sci Total Environ. 2023 Mar 1; 862:160700. doi: 10.1016/j.scitotenv.2022.160700.


Gåsland H, Trier NH, Kyllesbech C, Draborg AH, Slibinskas R, Ciplys E, Frederiksen JL, Houen G: Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis. Immunol Lett. 2023 Feb;254:54-64. doi: 10.1016/j.imlet.2023.02.003.


Zukauskas S, Rucinskiene A, Ratautaite V, Ramanaviciene A, Pilvenyte G, Bechelany M, Ramanavicius A: Electrochemical Biosensor for the Determination of Specific Antibodies against SARS-CoV-2 Spike Protein. Int J Mol Sci. 2022 Dec 31; 24(1):718. doi: 10.3390/ijms24010718.


Plikusiene I, Maciulis V, Juciute S, Ramanavicius A, Balevicius Z, Slibinskas R, Kucinskaite-Kodze I, Simanavicius M, Balevicius S, Ramanaviciene A: Investigation of SARS-CoV-2 nucleocapsid protein interaction with a specific antibody by combined spectroscopic ellipsometry and quartz crystal microbalance with dissipation. J Colloid Interface Sci. 2022 Nov 15; 626:113-122. doi: 10.1016/j.jcis.2022.06.119. Full text.


Drobysh M, Liustrovaite V, Baradoke A, Viter R, Chen CF, Ramanavicius A, Ramanaviciene A: Determination of rSpike Protein by Specific Antibodies with Screen-Printed Carbon Electrode Modified by Electrodeposited Gold Nanostructures. Biosensors (Basel). 2022 Aug 3; 12(8):593. doi: 10.3390/bios12080593.


Mughal FP, Bergmann AC, Huynh HUB, Jørgensen SH, Mansha I, Kesmez M, Schürch PM, Theocharides APA, Hansen PR, Friis T, Holmström MO, Ciplys E, Slibinskas R, Højrup P, Houen G, Trier NH: Production and Characterization of Peptide Antibodies to the C-Terminal of Frameshifted Calreticulin Associated with Myeloproliferative Diseases. Int J Mol Sci. 2022 Jun 18;23(12):6803. doi: 10.3390/ijms23126803.


Drobysh M, Liustrovaite V, Baradoke A, Rucinskiene A, Ramanaviciene A, Ratautaite V, Viter R, Chen CF, Plikusiene I, Samukaite-Bubniene U, Slibinskas R, Ciplys E, Simanavicius M, Zvirbliene A, Kucinskaite-Kodze I, Ramanavicius A: Electrochemical Determination of Interaction between SARS-CoV-2 Spike Protein and Specific Antibodies. Int J Mol Sci. 2022 Jun 17; 23(12):6768. doi: 10.3390/ijms23126768.


Kyllesbech C, Trier N, Slibinskas R, Ciplys E, Tsakiri A, Frederiksen JL, Houen G: Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis. J Neuroimmunol. 2022 Jun 15;367:577868. doi: 10.1016/j.jneuroim.2022.577868.


Plikusiene I, Maciulis V, Juciute S, Maciuleviciene R, Balevicius S, Ramanavicius A, Ramanaviciene A: Investigation and Comparison of Specific Antibodies’ Affinity Interaction with SARS-CoV-2 Wild-Type, B.1.1.7, and B.1.351 Spike Protein by Total Internal Reflection Ellipsometry. Biosensors (Basel). 2022 May 18; 12(5):351. doi: 10.3390/bios12050351. Full text.


Zinkevičiūtė R, Ražanskas R, Kaupinis A, Macijauskaitė N, Čiplys E, Houen G, Slibinskas R: Yeast Secretes High Amounts of Human Calreticulin without Cellular Stress. Curr Issues Mol Biol. 2022 Apr 19;44(5):1768-1787. doi: 10.3390/cimb44050122.


Trier NH, Valdarnini N, Fanelli I, Rovero P, Hansen PR, Schafer-Nielsen C, Ciplys E, Slibinskas R, Pociot F, Friis T, Houen G: Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C. Int J Mol Sci. 2022 Apr 17;23(8):4424. doi: 10.3390/ijms23084424.


Liustrovaite V.; Drobysh, M.; Rucinskiene, A.; Baradoke, A.; Ramanaviciene, A.; Plikusiene, I.; Samukaite-Bubniene, U.; Viter, R.; Chen, C.-F.; Ramanavicius, A. Towards an Electrochemical Immunosensor for the Detection of Antibodies against SARS-CoV-2 Spike Protein. J. Electrochem. Soc. 2022, 169, 037523. DOI: 10.1149/1945-7111/ac5d91.


Lučiūnaitė A, Dalgėdienė I, Žilionis R, Mašalaitė K, Norkienė M, Šinkūnas A, Gedvilaitė A, Kučinskaitė-Kodzė I, Žvirblienė A: Activation of NLRP3 Inflammasome by Virus-Like Particles of Human Polyomaviruses in Macrophages. Front Immunol. 2022 Mar 9;13:831815. doi: 10.3389/fimmu.2022.831815.


Ratautaite V, Boguzaite R, Brazys E, Ramanaviciene A, Ciplys E, Juozapaitis M, Slibinskas R, Bechelany M, Ramanavicius A: Molecularly imprinted polypyrrole based sensor for the detection of SARS-CoV-2 spike glycoprotein. Electrochim Acta. 2022 Jan 20; 403:139581. doi: 10.1016/j.electacta.2021.139581.


Čiplys E, Paškevičius T, Žitkus E, Bielskis J, Ražanskas R, Šneideris T, Smirnovas V, Kaupinis A, Tester DJ, Ackerman MJ, Højrup P, Michalak M, Houen G, Slibinskas R: Mapping human calreticulin regions important for structural stability. Biochim Biophys Acta Proteins Proteom. 2021 Nov;1869(11):140710. doi: 10.1016/j.bbapap.2021.140710.


Bergmann AC, Kyllesbech C, Slibinskas R, Ciplys E, Højrup P, Trier NH, Houen G: Epitope Mapping of Monoclonal Antibodies to Calreticulin Reveals That Charged Amino Acids Are Essential for Antibody Binding. Antibodies (Basel). 2021 Aug 4;10(3):31. doi: 10.3390/antib10030031.


Plikusiene I, Maciulis V, Ramanaviciene A, Balevicius Z, Buzavaite-Verteliene E, Ciplys E, Slibinskas R, Simanavicius M, Zvirbliene A, Ramanavicius A: Evaluation of kinetics and thermodynamics of interaction between immobilized SARS-CoV-2 nucleoprotein and specific antibodies by total internal reflection ellipsometry. J Colloid Interface Sci. 2021 Jul 15; 594:195-203. doi: 10.1016/j.jcis.2021.02.100. Full text.


Hiebert J, Zubach V, Charlton CL, Fenton J, Tipples GA, Fonseca K, Severini A: Evaluation of Diagnostic Accuracy of Eight Commercial Assays for the Detection of Measles Virus-Specific IgM Antibodies. J Clin Microbiol. 2021 May 19;59(6):e03161-20. doi: 10.1128/JCM.03161-20.


Houen G, Heiden J, Trier NH, Draborg AH, Benros ME, Zinkevičiūtė R, Petraitytė-Burneikienė R, Ciplys E, Slibinskas R, Frederiksen JL: Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis. J Neuroimmunol. 2020 Jul 7;346:577314. doi: 10.1016/j.jneuroim.2020.577314.


Bulavaitė A, Lasickienė R, Tamošiūnas PL, Simanavičius M, Sasnauskas K, Žvirblienė A: Synthesis of human parainfluenza virus 4 nucleocapsid-like particles in yeast and their use for detection of virus-specific antibodies in human serum. Appl Microbiol Biotechnol. 2017 Apr;101(7):2991-3004. doi: 10.1007/s00253-017-8104-0.


Boelt SG, Norn C, Rasmussen MI, André I, Čiplys E, Slibinskas R, Houen G, Højrup P: Mapping the Ca(2+) induced structural change in calreticulin. J Proteomics. 2016 Jun 16;142:138-48. doi: 10.1016/j.jprot.2016.05.015.


Čiplys E, Žitkus E, Gold LI, Daubriac J, Pavlides SC, Højrup P, Houen G, Wang WA, Michalak M, Slibinskas R: High-level secretion of native recombinant human calreticulin in yeast. Microb Cell Fact. 2015 Oct 15;14(1):165.


Shonhai A, Warrener L, Mangwanya D, Slibinskas R, Brown K, Brown D, Featherstone D, Samuel D: Investigation of a measles outbreak in Zimbabwe, 2010: potential of a point of care test to replace laboratory confirmation of suspected cases. Epidemiol Infect. 2015 Dec;143(16):3442-50.


Korbelik M, Banáth J, Saw KM, Zhang W, Čiplys E: Calreticulin as cancer treatment adjuvant: combination with photodynamic therapy and photodynamic therapy-generated vaccines. Front Oncol. 2015 Feb 3;5:15.


Čiplys E, Aučynaitė A, Slibinskas R: Generation of human ER chaperone BiP in yeast Saccharomyces cerevisiae. Microb Cell Fact. 2014 Feb 11;13:22.


Čiplys E, Žitkus E, Slibinskas R: Native signal peptide of human ERp57 disulfide isomerase mediates secretion of active native recombinant ERp57 protein in yeast Saccharomyces cerevisiae. Protein Expr Purif. 2013 Jun;89(2):131-5.


Warrener L, Slibinskas R, Chua KB, Nigatu W, Brown KE, Sasnauskas K, Samuel D, Brown D: A point-of-care test for measles diagnosis: detection of measles-specific IgM antibodies and viral nucleic acid. Bull World Health Organ. 2011 Sep 1;89(9):675-82.


Warrener L, Slibinskas R, Brown D, Sasnauskas K, Samuel D: Development and evaluation of a rapid immunochromatographic test for mumps-specific IgM in oral fluid specimens and use as a matrix for preserving viral nucleic acid for RT-PCR. J Med Virol. 2010 Mar;82(3):485-93.


Juozapaitis M, Zvirbliene A, Kucinskaite I, Sezaite I, Slibinskas R, Coiras M, de Ory Manchon F, López-Huertas MR, Pérez-Breña P, Staniulis J, Narkeviciute I, Sasnauskas K: Synthesis of recombinant human parainfluenza virus 1 and 3 nucleocapsid proteins in yeast Saccharomyces cerevisiae. Virus Res. 2008 May;133(2):178-86.


Slibinskas R, Samuel D, Gedvilaite A, Staniulis J, Sasnauskas K: Synthesis of the measles virus nucleoprotein in yeast Pichia pastoris and Saccharomyces cerevisiae. J Biotechnol. 2004 Jan 22;107(2):115-24.


Samuel D, Sasnauskas K, Jin L, Gedvilaite A, Slibinskas R, Beard S, Zvirbliene A, Oliveira SA, Staniulis J, Cohen B, Brown D: Development of a measles specific IgM ELISA for use with serum and oral fluid samples using recombinant measles nucleoprotein produced in Saccharomyces cerevisiae. J Clin Virol. 2003 Oct;28(2):121-9.


Slibinskas R, Zvirbliene A, Gedvilaite A, Samuel D, Jin L, Beard S, Staniulis J, Sasnauskas K: Synthesis of mumps virus nucleocapsid protein in yeast Pichia pastoris. J Biotechnol. 2003 Jun 12;103(1):43-9.


 

BALTYMAS patent applications:

 

Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. Generation of native recombinant secreted human endoplasmic reticulum chaperones by using their native signal sequences in yeast expression systems. PCT patent application WO 2014011723 A1. Publication date 2014-01-16 (also published as: CA2878672 (A1) 2014-01-16, CA2878672 (C) 2020-04-07; EP2872644 (A1) 2015-05-20, EP2872644 (A4) 2016-03-23; EP 2872644 (B1) 2017-07-12; US20150191713 (A1) 2015-07-09; US9796971 (B2) 2017-10-24; CN104704126 (A) 2015-06-10; CN104704126 (B) 2018-03-20; IL236663D (D0) 2015-02-26, IL236663 (A) 2018-10-31; in India – Appl. No. 723/CHENP/2015 (A) 2016-07-01).

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014011723


Slibinskas R, Čiplys E. Treatment of eye disease. Priority forming UK patent application No: 1914516.8. Filed October 8, 2019.

https://patents.google.com/patent/GB201914516D0/


Slibinskas R, Čiplys E. Calreticulin for treating or preventing an angiogenic eye disease. PCT patent application WO 2021069523 A1. Publication date 2021-04-15 (also published as: KR20220079917 (A) 2022-06-14; EP4041280 (A1) 2022-08-17; US20220370554 (A1) 2022-11-24; JP2023500033 (A1) 2023-01-04).

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021069523


 

Baltymas Patents (All active):

Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. European patent EP 2 872 644 B1. 2017 Jul 12.

https://register.epo.org/application?number=EP13816756


Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. US patent # 9,796,971 B2. 2017 Oct 24.

https://patents.google.com/patent/US9796971


Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. Chinese patent CN104704126 (B). 2018 Mar 20. https://patents.google.com/patent/CN104704126B/en


Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. Israel patent IL 236663. 2019 Feb 01. http://www.ilpatsearch.justice.gov.il/UI/RequestDetails.aspx?ReqId=236663


Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. Indian patent No. 326401. 2019 Nov 29.


Čiplys E, Slibinskas R, Sasnauskas K, Michalak M, Gold LI. Canadian patent No. CA 2878672 C. 2020 Apr 07.

https://patents.google.com/patent/CA2878672C/